Background Recently, I was presenting approach to Thrombotic Microangiopathy in hospital. I made the following notes, which I feel will be beneficial for the residents.
Introduction TMA are of diverse etiologies but have unified manifestation
a. MAHA (Coombs negative, increased LDH, schistocytes)
b. Thrombocytopenia
c. Organ injury (ischemic)
TMA has unified pathogenesis
a. Endothelial dysfunction
b. Microinfarcts
Approach to treatment
a. Primary TMA syndromes (ADAMTS deficiency, HUS): treatment to be of the cause