Thrombosis

Bleeding and Thrombosis: A double edged sword

Background Based on the thrombotic potential, the processes in human body can be classified into prothrombotic and antithrombotic processes. The prothrombotic processes are needed to prevent leakage of blood from the vasculature outside (bleeding) after its disruption. The antithrombotic processes are needed to prevent blood form getting clotted inside intact vasculature. Prothrombotic process The process consist of the tissue factor and vWF from the subendothelial layer; phospholipids from the platelets, erythrocytes and activated endothelium; activated platelets; coagulation factors and antifibrinolytic system (which prevents the fibrin degradation).

Bleeding and Thrombosis: A double edged sword