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Study The study in question is the ALCYONE Trial, published in NEJM in 12 December 2017 by María-Victoria Mateos, Meletios A Dimopoulos, et al. The investigators studied the effect of adding Daratumumab with Bortezomib, Melphalan and Prednisolone in patients with freshly detected Myeloma ineligible for Autologous Bone Marrow Transplantation. The study arms were Arm 1: Daratumumab + Bortezomib + Melphalan + Prednisolone and Arm 2: Bortezomib + Melphalan + Prednisolone

Introduction I was recently working on a PDF file with 60 odd pages and I had to crop the lower border of the pages. ImageMagick ImageMagick is GNU image editing program in Linux. Recently a package named magick has been created by rOpenSci. Steps of batch manipulation of PDF pages Loading PDF pages The PDF pages are loaded as vector of image object pdf <- image_read("path_file.pdf") We can access page i with